{"id":5931,"date":"2024-03-12T16:00:44","date_gmt":"2024-03-12T08:00:44","guid":{"rendered":"https:\/\/chimebiologics.com\/?p=5931"},"modified":"2025-06-12T14:07:59","modified_gmt":"2025-06-12T06:07:59","slug":"domain-therapeutics-and-chime-biologics-announce-manufacturing-agreement-to-advance-novel-anti-ccr8-antibody-for-cancer-immunotherapy","status":"publish","type":"post","link":"https:\/\/chimebiologics.com\/zh\/domain-therapeutics-and-chime-biologics-announce-manufacturing-agreement-to-advance-novel-anti-ccr8-antibody-for-cancer-immunotherapy\/","title":{"rendered":"Domain Therapeutics \u4e0e\u9f0e\u5eb7\u751f\u7269\u5ba3\u5e03\u8fbe\u6210\u751f\u4ea7\u534f\u8bae\uff0c\u63a8\u52a8\u65b0\u578b\u6297CCR8 \u6297\u4f53\u7528\u4e8e\u764c\u75c7\u514d\u75ab\u7597\u6cd5"},"content":{"rendered":"<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-iwqe2-97bb6aa3783a5420eb8a707e0ad897c8\">\n.flex_column.av-iwqe2-97bb6aa3783a5420eb8a707e0ad897c8{\n-webkit-border-radius:0px 0px 0px 0px;\n-moz-border-radius:0px 0px 0px 0px;\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div class='flex_column av-iwqe2-97bb6aa3783a5420eb8a707e0ad897c8 av_two_third  avia-builder-el-0  el_before_av_two_third  avia-builder-el-first  first flex_column_div av-zero-column-padding '     ><section  class='av_textblock_section av-k6j2pxor-09272cddfdcc1afe6211303b3b3d55e0'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/BlogPosting\" itemprop=\"blogPost\" ><div class='avia_textblock'  itemprop=\"text\" ><div class=\"mceTemp\"><\/div>\n<p><\/p>\n<h1><strong>Domain Therapeutics <\/strong><strong>\u4e0e\u9f0e\u5eb7\u751f\u7269<\/strong><strong>\u5ba3\u5e03\u8fbe\u6210\u751f\u4ea7\u534f\u8bae\uff0c<\/strong><strong>\u63a8\u52a8\u65b0\u578b\u6297CCR8 \u6297\u4f53\u7528\u4e8e\u764c\u75c7\u514d\u75ab\u7597\u6cd5<\/strong><\/h1>\n<p><a href=\"https:\/\/chimebiologics.com\/wp-content\/uploads\/2024\/03\/9767d405-4a42-4920-bf40-d2de7d681a83.png\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-5937 aligncenter\" src=\"https:\/\/chimebiologics.com\/wp-content\/uploads\/2024\/03\/9767d405-4a42-4920-bf40-d2de7d681a83.png\" alt=\"\" width=\"900\" height=\"383\" srcset=\"https:\/\/chimebiologics.com\/wp-content\/uploads\/2024\/03\/9767d405-4a42-4920-bf40-d2de7d681a83.png 900w, https:\/\/chimebiologics.com\/wp-content\/uploads\/2024\/03\/9767d405-4a42-4920-bf40-d2de7d681a83-300x128.png 300w, https:\/\/chimebiologics.com\/wp-content\/uploads\/2024\/03\/9767d405-4a42-4920-bf40-d2de7d681a83-768x327.png 768w, https:\/\/chimebiologics.com\/wp-content\/uploads\/2024\/03\/9767d405-4a42-4920-bf40-d2de7d681a83-705x300.png 705w\" sizes=\"auto, (max-width: 900px) 100vw, 900px\" \/><\/a><\/p>\n<ul>\n<li><em><strong>\u57fa\u4e8e\u9f0e\u5eb7\u751f\u7269\u56fd\u9645\u5316\u7684\u7814\u53d1\u4e0e\u751f\u4ea7\u80fd\u529b\uff0cDomain Therapeutics\u5c06\u5019\u9009\u836f\u7269 DT-7012\u59d4\u6258\u7ed9\u9f0e\u5eb7\u751f\u7269\uff0c\u9f0e\u5eb7\u751f\u7269\u63d0\u4f9b\u4ece\u7ec6\u80de\u682a\u5f00\u53d1\u5230\u4e34\u5e8aGMP \u751f\u4ea7\u7684\u6574\u4f53\u5316\u670d\u52a1<\/strong><\/em><\/li>\n<li><em><strong>2023 \u5e74 6 \u6708\uff0cDomain \u786e\u5b9a\u4e86\u5019\u9009\u5206\u5b50DT-7012\uff0c \u662f\u4e00\u79cd\u53ef\u6e05\u9664\u8c03\u8282\u6027T\u7ec6\u80de\uff08Treg\uff09\u7684\u6297 CCR8 \u5355\u514b\u9686\u6297\u4f53 (mAb)\uff0c\u8fd9\u4e2a\u6f5c\u5728\u7684best-in-class\u836f\u7269\u5c06\u4e8e 2025 \u5e74\u8fdb\u5165\u4e34\u5e8a I \u671f\u7814\u7a76<\/strong><\/em><\/li>\n<li><em><strong>CCR8 GPCR \u9776\u70b9\u662f\u6781\u5177\u6f5c\u529b\u7684\u80bf\u7624\u514d\u75ab\u9776\u70b9\uff0c\u53ef\u63d0\u9ad8\u5bf9\u73b0\u6709\u6cbb\u7597\u65e0\u5e94\u7b54\u60a3\u8005\u7684\u4e34\u5e8a\u6210\u529f\u7387\uff0c\u6709\u52a9\u4e8e\u764c\u75c7\u7684\u6cbb\u7597<\/strong><\/em><\/li>\n<\/ul>\n<p><strong>\u6cd5\u56fd\u65af\u7279\u62c9\u65af\u5821<\/strong><strong> - <\/strong><strong>\u7f8e\u56fd\u6ce2\u58eb\u987f<\/strong><strong> - <\/strong><strong>\u4e2d\u56fd\u4e0a\u6d77\uff0c<\/strong><strong>2024<\/strong><strong>\u5e74<\/strong><strong>3<\/strong><strong>\u6708<\/strong><strong>12<\/strong><strong>\u65e5<\/strong> - Domain Therapeutics\uff08\u4ee5\u4e0b\u7b80\u79f0 \"Domain\"\uff09\uff0c\u4e00\u5bb6\u5904\u4e8e\u4e34\u5e8a\u9636\u6bb5\u7684\u5168\u7403\u6027\u751f\u7269\u5236\u836f\u516c\u53f8\uff0c\u6b63\u5728\u5f00\u53d1\u4ee5G\u86cb\u767d\u5076\u8054\u53d7\u4f53\uff08GPCRs\uff09\u4e3a\u9776\u70b9\u7684\u514d\u75ab\u80bf\u7624\u5b66\u521b\u65b0\u5019\u9009\u836f\u7269\u3002Domain\u4eca\u65e5\u5ba3\u5e03\u4e0e\u9f0e\u5eb7\u751f\u7269\uff08Chime Biologics\uff09\uff0c\u4e00\u5bb6\u5168\u7403\u9886\u5148\u7684\u56fd\u9645\u5316CDMO\u516c\u53f8\uff0c\u5171\u540c\u7b7e\u7f72\u4e00\u9879\u5168\u7403\u7814\u53d1\u548c\u751f\u4ea7\u670d\u52a1\u534f\u8bae\uff0c\u7528\u4e8e\u63a8\u52a8Domain\u7684\u53ef\u6e05\u9664\u8c03\u8282\u6027T\u7ec6\u80de\uff08Treg\uff09\u7684\u6297 CCR8 \u6297\u4f53\u5019\u9009\u836f\u7269 DT-7012\u8fdb\u5165\u4e34\u5e8a\uff0cDT-7012\u662f\u4e00\u6b3e\u6f5c\u5728\u201cbest-in-class\u201d\u5019\u9009\u836f\u7269\uff0c\u8be5\u4ea7\u54c1\u53ef\u4ee5\u4e3a\u5168\u7403\u764c\u75c7\u60a3\u8005\u63d0\u4f9b\u65b0\u7684\u6cbb\u7597\u65b9\u5f0f\u3002<\/p>\n<p>\u6839\u636e\u534f\u8bae\u6761\u6b3e\uff0c\u9f0e\u5eb7\u751f\u7269\u5c06\u4e3a\u5019\u9009\u836f\u7269DT-7012\u63d0\u4f9b\u4ece\u7ec6\u80de\u682a\u5f00\u53d1\uff0c\u5de5\u827a\u5f00\u53d1\uff0c\u5de5\u827a\u653e\u5927\u548c\u4e34\u5e8aI \u671fGMP\u751f\u4ea7\u7684\u6574\u4f53\u5316\u670d\u52a1\uff0c\u5e76\u652f\u6301Domain\u5728\u5168\u7403\u591a\u4e2a\u56fd\u5bb6\u5f00\u5c55\u4e34\u5e8a\u8bd5\u9a8c\u3002\u9f0e\u5eb7\u751f\u7269\u62e5\u6709\u5168\u7403\u9996\u4e2a\u6a21\u5757\u5316\u5de5\u5382KUBio\uff0c\u91c7\u7528\u4e00\u6b21\u6027\u751f\u7269\u5de5\u827a\u6280\u672f\uff0c\u7b26\u5408\u56fd\u9645 cGMP \u6807\u51c6\uff0c\u5e76\u62e5\u6709\u591a\u5e74\u4f18\u79c0\u7684\u5ba1\u8ba1\u8ddf\u8e2a\u8bb0\u5f55\u3002\u9f0e\u5eb7\u751f\u7269\u76ee\u524d\u5df2\u7ecf\u4e3a\u5168\u740330\u591a\u4e2a\u56fd\u5bb6\u548c\u5730\u533a\u4e34\u5e8a\u4f9b\u6837\u30022022\u5e74\u662f\u9f0e\u5eb7\u751f\u7269\u7684\u5546\u4e1a\u5316\u751f\u4ea7\u5143\u5e74\uff0c\u591a\u4e2a\u5546\u4e1a\u5316\u751f\u4ea7\u9879\u76ee\u5df2\u7ecf\u5728\u9f0e\u5eb7\u5f00\u5c55\uff0c\u5168\u9762\u6253\u5f00\u4e86\u56fd\u9645\u5316\u4e4b\u8def\u3002<\/p>\n<p>DT-7012\u662f\u4e00\u79cd\u65b0\u578b\u6297CCR8\u5355\u514b\u9686\u6297\u4f53\uff0c\u53ef\u6e05\u9664\u80bf\u7624\u6d78\u6da6\u7684\u4e3b\u8981\u514d\u75ab\u6291\u5236\u7ec6\u80de\u7684Treg\u3002\u4f5c\u4e3a\u4e00\u79cd\u5355\u4e00\u7597\u6cd5\uff0c\u6297CCR8\u5355\u6297\u5bf9Treg\u7684\u6e05\u9664\u5df2\u663e\u793a\u51fa\u72ec\u7279\u7684\u6297\u80bf\u7624\u6548\u529b\u3002\u4e0e\u5176\u4ed6\u5904\u4e8e\u4e34\u5e8a\u9636\u6bb5\u7684 CCR8 \u6297\u4f53\u76f8\u6bd4\uff0cDT-7012 \u5df2\u8bc1\u660e\u5177\u6709best-in-class\u7684\u6f5c\u529b\uff0c\u4e3a\u6709\u6548\u7684 GPCR \u9776\u5411\u514d\u75ab\u7597\u6cd5\u94fa\u5e73\u4e86\u9053\u8def\uff0c\u65e8\u5728\u6fc0\u6d3b\u5bf9\u5176\u4ed6\u7597\u6cd5\u65e0\u53cd\u5e94\u7684\u764c\u75c7\u60a3\u8005\u7684\u6297\u80bf\u7624\u514d\u75ab\u529b\u3002DT-7012\u9884\u8ba1\u5c06\u4e8e 2025 \u5e74\u521d\u5f00\u59cb\u8fdb\u884c\u4e3b\u8981\u9488\u5bf9\u5b9e\u4f53\u7624\u7684\u4e34\u5e8aI \u671f\u7814\u7a76\uff0c\u5e76\u4e8e 2025 \u5e74\u4e2d\u5f00\u59cb\u8fdb\u884c\u4e3b\u8981\u9488\u5bf9\u76ae\u80a4 T \u7ec6\u80de\u6dcb\u5df4\u7624 \uff08CTCL\uff09\u7684\u4e34\u5e8aI \u671f\u7814\u7a76\u3002<\/p>\n<p><strong>\u9f0e\u5eb7\u751f\u7269\u603b\u88c1\u9b4f\u5efa\u4e2d\uff08<\/strong><strong>Jimmy Wei<\/strong><strong>\uff09\u535a\u58eb<\/strong>\u8868\u793a\uff1a\"\u6211\u4eec\u5f88\u8363\u5e78\u80fd\u4e0e\u6cd5\u56fdDomain\u516c\u53f8\u5728\u9886\u5148\u7684\u6297CCR8\u6297\u4f53\u5019\u9009\u836f\u7269\u4e0a\u8fbe\u6210\u91cd\u5927\u7684\u5408\u4f5c\uff0c\u5171\u540c\u63a8\u52a8\u6cbb\u7597\u591a\u79cd\u764c\u75c7\u7684best-in-class \u836f\u7269\u7684\u5546\u4e1a\u5316\u8fdb\u7a0b\u3002\u9f0e\u5eb7\u751f\u7269\u5c06\u4f1a\u4ece\u7ec6\u80de\u682a\u5f00\u53d1\u5230\u4e34\u5e8aGMP\u751f\u4ea7\u63d0\u4f9b\u4e00\u7ad9\u5f0f\u7684CMC\u670d\u52a1\uff0c\u52a9\u529b\u8be5\u836f\u7269\u65e9\u65e5\u9020\u798f\u66f4\u591a\u75c5\u60a3\u3002\u81ea2022\u5e7410\u6708\u5efa\u7acb\u6b27\u6d32\u5546\u52a1\u4e2d\u5fc3\u4ee5\u6765\uff0c\u6211\u4eec\u6b27\u6d32\u4e1a\u52a1\u8fc5\u901f\u53d1\u5c55\uff0c\u4eca\u540e\u6211\u4eec\u5c06\u8fdb\u4e00\u6b65\u52a0\u5927\u6295\u5165\uff0c\u66f4\u597d\u5730\u670d\u52a1\u50cfDomain\u8fd9\u6837\u7684\u6b27\u6d32\u521b\u65b0\u751f\u7269\u533b\u836f\u4f01\u4e1a\u3002\u201d<\/p>\n<p><strong>Domain Therapeutics \u9996\u5e2d\u79d1\u5b66\u5bb6\uff08SCO\uff09 Stephan Schann<\/strong> \u8868\u793a\uff1a \"\u6211\u4eec\u5f88\u9ad8\u5174\u80fd\u4e0e\u9f0e\u5eb7\u751f\u7269\u8fd9\u6837\u4f18\u79c0\u7684\u56fd\u9645\u5316\u751f\u7269\u836fCDMO\u4e13\u5bb6\u5408\u4f5c\uff0c\u5c06\u6211\u4eec\u9886\u5148\u7684\u6297CCR8\u5019\u9009\u836f\u7269DT-7012\u63a8\u5411\u4e0b\u4e00\u4e2a\u9636\u6bb5\u3002\u8fd9\u79cd\u65b0\u578b GPCR \u9776\u5411\u514d\u75ab\u7597\u6cd5\u6f5c\u529b\u5de8\u5927\uff0c\u53ef\u4ee5\u89e3\u9501\u514d\u75ab\u7cfb\u7edf\u7684\u6297\u764c\u80fd\u529b\uff0c\u9020\u798f\u5168\u7403\u60a3\u8005\u3002\u5728 Domain\uff0c\u6211\u4eec\u4f18\u5148\u8003\u8651\u7cbe\u51c6\u7814\u7a76\u548c\u521b\u65b0\uff0c\u5e76\u6b22\u8fce\u4e0e\u6211\u4eec\u6709\u5171\u540c\u613f\u666f\u548c\u70ed\u60c5\u7684\u7ec4\u7ec7\u6210\u4e3a\u65b0\u7684\u5408\u4f5c\u4f19\u4f34\uff0c\u5171\u540c\u63a8\u8fdb\u514d\u75ab\u80bf\u7624\u5b66\u7684\u53d1\u5c55\u3002\u201d<\/p>\n<p><strong>\u5173\u4e8eDomain Therapeutics<\/strong><\/p>\n<p>Domain Therapeutics, a clinical-stage global biopharmaceutical company, focused on developing innovative immunotherapies targeting G Protein-Coupled Receptors (GPCRs), one of the most important drug target classes, to unlock new possibilities in cancer. As a leader in GPCRs in immuno-oncology, Domain sees cancer differently, using a precise biomarker strategy to address the specific needs of patients based on unique signatures of individual cancers. Two decades of solid experience in GPCR drug discovery, validated by multiple pharma partnerships, associated to a target identification and drug discovery platform enable the Company to enhance the understanding of cancer and deliver innovative immunotherapies to patients.<\/p>\n<p>Domain\u2019s proprietary programs include DT-7012, a Treg-depleting CCR8 antibody, DT-9045, a first-in-class PAR2 negative allosteric modulator, and DT-9081, an EP4 receptor antagonist alongside the \u00a0M1069, an A2aR\/A2b receptor antagonist identified in partnership with Merck KGaA. The company has also an optimized pipeline of best-in-class and first-in-class GPCR targets selected through Domain\u2019s proprietary cross-validation drug discovery and development platform.<\/p>\n<p>Domain is part of the SPRINT university hospital research project (RHU), a French consortium, led by Dr Ad\u00e8le DE MASSON, directed by Paris Cit\u00e9 University and funded by the French government as part of the France 2030 implemented by ANR, to advance precision medicine for patients with cutaneous T-cell lymphoma.<\/p>\n<p>Since 2022, the Company raised \u20ac51m ($55m) in series A \u00a0to progress preclinical and clinical development of its high-value drug candidates to address GPCR-mediated immunosuppression. Domain is supported by leading international venture capital firms from Europe (3B Future Health Fund, Seventure, Schroders, Omnes, Turenne, Theodorus), Asia (Panacea and Viva) and North America (CTI Life Science, adMare).<\/p>\n<p>For more information, please visit: <a href=\"http:\/\/www.domaintherapeutics.com\">www.domaintherapeutics.com<\/a><\/p>\n<p><strong>\u5173\u4e8e\u9f0e\u5eb7\u751f\u7269<\/strong><\/p>\n<p>\u9f0e\u5eb7\u751f\u7269\u662f\u4e00\u5bb6\u5168\u7403\u9886\u5148\u7684CDMO\u516c\u53f8\uff0c\u7387\u5148\u5f15\u8fdb\u4e86\u5168\u7403\u9996\u4e2a\u6a21\u5757\u5316\u751f\u7269\u5236\u836f\u5de5\u5382KUBio\uff0c\u8d4b\u80fd\u751f\u7269\u5236\u54c1\u4ece\u7ec6\u80de\u682a\u5f00\u53d1\u5230\u5546\u4e1a\u5316\u751f\u4ea7\u7684\u5168\u8fc7\u7a0b\u3002\u6211\u4eec\u4f4d\u4e8e\u4e0a\u6d77\u7684\u521b\u65b0\u4e2d\u5fc3\u805a\u7126\u9ad8\u6548\u7684\u7ec6\u80de\u682a\u5f00\u53d1\u548c\u5148\u8fdb\u7684\u6280\u672f\u5f00\u53d1\uff0c\u4e0e\u62e5\u6709\u591a\u56fd\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\u548c\u65b0\u836f\u4e0a\u5e02\u6210\u529f\u7ecf\u9a8c\u7684\u6b66\u6c49\u5236\u9020\u5de5\u5382\u76f8\u7ed3\u5408\uff0c\u9f0e\u5eb7\u751f\u7269\u6b63\u5728\u4e3a\u5168\u7403\u751f\u7269\u533b\u836f\u5ba2\u6237\u63d0\u4f9b\u4e00\u7ad9\u5f0f\u7684CMC\u89e3\u51b3\u65b9\u6848\u3002\u5728\u9f0e\u5eb7\u751f\u7269,\u6211\u4eec\u6709\u4e00\u4e2a\u5171\u540c\u7684\u76ee\u6807, \u81f4\u529b\u4e8e\u63d0\u9ad8\u524d\u6cbf\u751f\u7269\u533b\u836f\u5bf9\u5168\u7403\u60a3\u8005\u7684\u53ef\u53ca\u6027\uff0c\u5c65\u884c\u6211\u4eec\u5bf9\u4eba\u7c7b\u5065\u5eb7\u7684\u627f\u8bfa\u3002\u5982\u9700\u4e86\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8bf7\u8bbf\u95ee: <a href=\"http:\/\/www.chimebiologics.com\" target=\"_blank\" rel=\"noopener\">www.chimebiologics.com<\/a>\u3002<\/p>\n<p><\/p>\n<\/div><\/section><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-av_two_third-1e26125d131ba13f1accaa8241be1528\">\n.flex_column.av-av_two_third-1e26125d131ba13f1accaa8241be1528{\n-webkit-border-radius:0px 0px 0px 0px;\n-moz-border-radius:0px 0px 0px 0px;\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div class='flex_column av-av_two_third-1e26125d131ba13f1accaa8241be1528 av_two_third  avia-builder-el-2  el_after_av_two_third  el_before_av_one_third  first flex_column_div av-zero-column-padding column-top-margin'     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